Synthesis, Characterization, in vitro Antimicrobial, and Anthelmintic Evaluations of N-(4, 6-dimethylpyrimidin-2-yl)-4-((2-hydroxynaphthalen-1-yl) diazenyl) Benzene Sulfonamide and Its Metal (II) Complexes
نویسندگان
چکیده
As a part of systematic investigation of biologically active compound, new azo dye ligand N-(4, 6-dimethylpyrimidin-2-yl)-4-((2-hydroxynaphthalen-1-yl) diazenyl) benzene sulfonamide has been synthesized by diazotization of 4-amino-N-(4, 6-dimethylpyrimidin-2-yl) benzenesulfonamide and coupled with coupling compound, naphthalen-2-ol. A new series of Ni (II), Cu (II), and Zn (II) complexes derived from this azo dye ligand (L) were synthesized. The structures of the ligand and metal complexes were confirmed by spectroscopic studies (elemental analysis, IR, 1H NMR and mass spectra). The azo dye and its complexes have been screened for their in vitro antimicrobial activities against some bacterial stains and fungal strains by disc diffusion method. The results showed that, the presence of metal causes more inhibition. The anthelmentic activity of the ligand and its complexes against adult Indian earthworms, Pheretima postuma are also investigated.
منابع مشابه
New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations
Synthesis new organic azo dye as reagent 3-((4-acetyl-3-hydroxyphenyl) diazenyl)-4-amino-N-(5-methylisoxazol3-yl)benzene sulfonamide (SDA) and Analytical Study of Co(II), Ni(II) and Cu(II), metals complexes. The reagent and its complexes were characterized by elemental analysis, UV-Vis, and molar conductivity measurements. The data show that the complexes have the composition of [MR]X2 type. Th...
متن کاملSynthesis and Characterization of New Mercury (II) Complexes with Bidentate Chelating Schiff Base Iminopyridine Ligand
First, Schiff base iminopyridine ligands has been prepared by the condensation between primaryamines, different substituted anilines and active carbonyl group of pyridine carboxaldehyde, thenthe complexes [diiodo (3-ethylphenyl) pyridine-2-yl methylene amine] mercury(II), complex a,[dibromo (2,5-dimethylphenyl) pyridine-2-yl methylene amine] mercury(II) complex b, and[dinitrato bis-(2,6-dimethy...
متن کاملDesign, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides
A series of novel isatine-sulphonamide derivatives have been synthesized by combining isatin derivatives with sulphonamides. The structure of the synthesized compounds were elucidated by spectral analysis (IR, NMR and Mass). Investigation of anti-HIV activity was done against HIV-1(IIIB) in MT-4 cells and HIV integrase inhibitory activity. 4-(1-acetyl-5-methyl-2-oxoindolin-3-ylideneamino)-N-(4,...
متن کاملSynthesis, Characterization and Study of In Vitro Antimicrobial Activity of Some Substituted N'-[Arylidene]-2-(5-Phenyl-1H- Tetrazol-1-yl) Acetohydrazide
Reaction of 5-phenyl tetrazole with ethyl chloroacetate to form ethyl (5-phenyl-1H-tetrazol-1-yl) acetate (1). Compound 1 react with hydrazine hydrate in ethanol yield 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide (2). The condensation of (2) with various aldehydes yield the corresponding substituted N'-[-arylidene]-2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide (3a- j). Th...
متن کاملSynthesis, Characterization and Study of Some N-Substituted Aryl-2- ({4-[(Substituted Aryl Carbamoyl) Methyl]-5-(Pyridin-4-yl)-4H-1, 2, 4-Triazol-3-yl} Sulfanyl) Acetamide
Pathogenic infections and inflammation are very common ailments humans suffer. Upsurge of resistant pathogens has impeded the antimicrobial drug development process in recent years and the search of new antimicrobial agents is clearly evident from the literature. In line with these developments the synthesis of N-substituted aryl-2-({4-[(substituted aryl carbamoyl) methyl]-5-(pyridin-4-yl)-4H-1...
متن کامل